Aminorex produces stimulus effects similar to
amphetamine and unlike those of fenfluramine

by
Young R
Department of Medicinal Chemistry,
Medical College of Virginia,
Virginia Commonwealth University,
Richmond 23298-0540.
Pharmacol Biochem Behav 1992 May; 42(1):175-8


ABSTRACT

A 4-methyl derivative of aminorex has recently appeared on the clandestine market as a designer drug. In the present study, the stimulus effects of aminorex itself were evaluated in rats trained to discriminate either 0.75 mg/kg S(+)-amphetamine or 1.5 mg/kg fenfluramine from saline. The amphetamine stimulus (ED50 = 0.14 mg/kg) generalized to aminorex (ED50 = 0.23 mg/kg), which was found to be slightly less potent than (+)-amphetamine. Fenfluramine stimulus generalization did not occur to aminorex. Thus, the stimulus effects of aminorex are qualitatively similar to those of amphetamine and unlike those of fenfluramine.
Aminorex
Stereotypies
Neurotoxicity
VTA/glutamate
CNS stimulants
Self-medication
Dopamine uptake
Psychotomimesis
Canine narcolepsy
Phenylpropanolamine
Appetite suppressants
4-Methylaminorex: structure



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