Withdrawal from chronic amphetamine induces
Depressive-Like behavioral effects in rodents

by
Cryan JF, Hoyer D, Markou A.
Department of Neuropharmacology (JFC, AM),
Scripps Research Institute, La Jolla, California, USA
Biol Psychiatry. 2003 Jul 1;54(1):49-58


ABSTRACT

Amphetamine withdrawal and major depression share many behavioral commonalties in humans. Therefore, the examination of the behavioral effects of amphetamine withdrawal in rodents may provide insights into the neurobiological mechanisms underlying both disorders and aid in the development of animal models of depression that are sensitive to antidepressant agents.WE EXAMINED THE BEHAVIORAL EFFECTS OF WITHDRAWAL FROM CHRONIC CONTINUOUS INFUSION OF AMPHETAMINE (VIA MINIPUMP) IN THREE BEHAVIORAL PARADIGMS: the intracranial self-stimulation (ICSS) procedure in rats, the modified forced swim test in rats, and the tail suspension test in mice.Amphetamine withdrawal resulted in a prolonged (5 day) deficit in brain reward function as assessed by elevations in ICSS thresholds. Using a similar regimen of amphetamine administration, we examined the behavioral effects of withdrawal in a modified rat forced swim test. Animals that were treated with the highest dose of amphetamine (10 mg/kg/day) exhibited increased climbing behavior and decreased immobility 24 hours after withdrawal; by the 48-hour testing time point, this effect had dissipated. In contrast, animals that had been pretreated with 5 mg/kg/day amphetamine exhibited a pronounced increase in immobility indicative of an increase in "depressive-like" behavior, coupled with decreases in swimming and climbing. In the mouse tail suspension test, both regimens of amphetamine pretreatment induced increases in immobility scores, also indicative of "depressive-like" behavior, 24 hours following withdrawal.Withdrawal from chronic amphetamine administration results in behavioral changes that may be analogous to some aspects of depression in humans, such as reward deficits (i.e., elevations in brain reward thresholds) and behaviors opposite to those seen after treatment with antidepressant drugs, such as decreased immobility in the forced swim test and the tail suspension test.
Ice
AD/HD
History
Adderall
Dexamyl
Serotonin
The Big Crash
VTA/glutamate
Self-medication
Worms on speed
Dopamine uptake
Canine narcolepsy
The dual deficit model
Methamphetamine FAQ
Amphetamine withdrawal and depression



Refs
and further reading

amphetamines.com
HOME
HedWeb
Nootropics
erythroxylum-coca.com
Cannabis.net
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhappiness?
Utopian Surgery?
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World