History of the methamphetamine problem
Anglin MD, Burke C, Perrochet B, Stamper E, Dawud-Noursi S
UCLA Drug Abuse Research Center/UCLA Department of Psychiatry;
UCLA/Matrix Coordinating Center for the CSAT Methamphetamine Treatment Project,
Los Angeles, USA.
J Psychoactive Drugs 2000 Apr-Jun; 32(2):137-41


Methamphetamine, called meth, crystal, or speed, is a central nervous system stimulant that can be injected, smoked, snorted, or ingested orally; prolonged use at high levels results in dependence. Methamphetamine (MA) is a derivative of amphetamine, which was widely prescribed in the 1950s and 1960s as a medication for depression and obesity, reaching a peak of 31 million prescriptions in the United States in 1967. Until the late 1980s, illicit use and manufacture of MA was endemic to California, but the MA user population has recently broadened in nature and in regional distribution, with increased use occurring in midwestern states. An estimated 4.7 million Americans (2.1% of the U.S. population) have tried MA at some time in their lives. Short- and long-term health effects of MA use include stroke, cardiac arrhythmia, stomach cramps, shaking, anxiety, insomnia, paranoia, hallucinations, and structural changes to the brain. Children of MA abusers are at risk of neglect and abuse, and the use of MA by pregnant women can cause growth retardation, premature birth, and developmental disorders in neonates and enduring cognitive deficits in children. MA-related deaths and admissions to hospital emergency rooms are increasing. Although inpatient hospitalization may be indicated to treat severe cases of long-term MA dependence, optimum treatment for MA abusers relies on an intensive outpatient setting with three to five visits per week of comprehensive counseling for at least the first three months. The burgeoning problems of increased MA use must be addressed by adequate treatment programs suitable for a variety of user types.
CNS stimulants
Dopamine uptake
Methamphetamine psychosis
The methamphetamine epidemic
Methamphetamine and memantine
Methamphetamine v MDMA toxicity
Amphetamine withdrawal/depression
Methamphetamine and dopamine transporters
Methamphetamine: a Weapon of Mass Destruction?
Methamphetamine : sensitization and desensitization
Methamphetamine (Desoxyn) - prescribing information (pdf)
Methamphetamine and dopamine/serotonin-releasing agents
Why is parkinsonism not a feature of methamphetamine users?

and further reading

Future Opioids
BLTC Research
Utopian Surgery?
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World