Three controlled trials of weight loss
with phenylpropanolamine

by
Altschuler S, Conte A, Sebok M,
Marlin RL, Winick C.
Int J Obes 1982;6(6):549-56


ABSTRACT

A multisite double-blind study was designed to determine the effectiveness of a phenylpropanolamine-caffeine combination in achieving weight loss. Two-hundred and one obese adult patients were divided into three separate groups in which phenylpropanolamine/caffeine was compared with either placebo (6 weeks), mazindol (6 weeks), or diethylpropion (8 weeks). In these clinical trials, phenylpropanolamine/caffeine proved to be as effective as mazindol and diethylpropion and significantly more effective than placebo in achieving weight loss. Overall, phenylpropanolamine/caffeine had fewer side effects than mazindol and diethylpropion. Its use as an effective anorectic agent in the treatment of obesity is reviewed.
PPA
Adderall
Pregnancy
Neurotoxicity
CNS stimulants
Dopamine uptake
Psychotomimesis
Appetite suppressants
Amphetamine withdrawal/depression
Phenylpropanolamine v pseudoephedrine



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