Increasing abuse of psychostimulants is alarming. New findings confirm the mechanisms behind cocaine and amphetamine addiction
by
Hurd Y, Lindefors N
Klinisk neurovetenskap,
Karolinska institutet, Stockholm.
Lakartidningen 1999 Apr 14; 96(15):1814-6, 1819-21


ABSTRACT

Amphetamine and cocaine are highly addictive psychostimulant drugs with potent actions on affect and motor activity. Psychostimulants exert their effects by interaction with monoamine transport carriers on cell membranes. Dopamine pathways extending from the brain stem to the basal ganglia, limbic structures, and cerebral cortex are generally considered to constitute the neuroanatomical substrates underlying motivation, reward, and motor function. Repeated use of psychostimulants is characterised by both tolerance (e.g., euphoria) and sensitisation (e.g., motor activation), and abstinence by craving and anhedonia. Neuronal systems, molecular alterations, and treatment regimens associated with psychostimulants are currently the subjects of discussion.
Driving
History
Adderall
Overdose
Pregnancy
Neurotoxicity
VTA/glutamate
CNS stimulants
Self-medication
Worms on speed
Dopamine uptake
Canine narcolepsy
Appetite suppressants
Methamphetamine psychosis
Methamphetamine/narcolepsy
Amphetamine and the angry mouse
Amphetamine withdrawal/depression



Refs
and further reading

amphetamines.com
HOME
HedWeb
Nootropics
Cocaine.org
Cannabis.net
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhappiness?
Utopian Surgery?
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World